The paths given to eSim possibly contains space characters in between them. When you launch eSim, an option window appears asking you to select a folder or path for eSim-Workspace. Choose one such folder or path which does not have spaces in them.
When creating a new project, please select a folder which will not have a space character in it.
And secondly, when opening a schematic, please store it in a folder/path, which does not have any spaces in them.